Professor

Additional Campus Affiliations

Professor, Chemical and Biomolecular Engineering
James W. Westwater Scholar, Chemical and Biomolecular Engineering
Affiliate, Chemistry
Professor, Bioengineering
Professor, National Center for Supercomputing Applications (NCSA)
Professor, Center for Digital Agriculture, National Center for Supercomputing Applications (NCSA)
Affiliate, Carl R. Woese Institute for Genomic Biology

Recent Publications

Clark, J. D., Dean, T. J., & Shukla, D. (2026). Learning physical interactions to compose biological large language models. Communications Chemistry, 9(1), Article 81. https://doi.org/10.1038/s42004-025-01883-7

Dean, T. J., Feng, J., & Shukla, D. (2026). How Minor Sequence Changes Enable Mechanistic Diversity in MFS Transporters? An Atomic-Level Rationale for Symport Emergence in NarU. Journal of Chemical Information and Modeling, 66(4), 2358-2368. https://doi.org/10.1021/acs.jcim.5c02971

Dutta, S., Zhao, L., & Shukla, D. (2026). Dynamic Mechanism for Subtype Selectivity of Endocannabinoids. Journal of Biological Chemistry, Article 111434. Advance online publication. https://doi.org/10.1016/j.jbc.2026.111434

Wang, B. M., Chiang, N., Ekas, H. M., Brown, D. M., Dildine, G., Lucci, T. J., Feng, S., Bly, V., Gaillard, J. F., Lucks, J. B., Karim, A. S., Shukla, D., & Jewett, M. C. (2026). Active learning-guided optimization of cell-free biosensors for lead testing in drinking water. Nature communications, 17(1), Article 261. https://doi.org/10.1038/s41467-025-66964-6

Barrett, S. E., Yin, S., Jordan, P., Brunson, J. K., Gordon-Nunez, J., Costa Machado da Cruz, G., Rosario, C., Okada, B. K., Anderson, K., Pires, T. A., Wang, R., Shukla, D., Burk, M. J., & Mitchell, D. A. (2025). Substrate interactions guide cyclase engineering and lasso peptide diversification. Nature chemical biology, 21(3), 412-419. https://doi.org/10.1038/s41589-024-01727-w

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