Atmospheric pressure chemical ionization (APCI) generally produces protonated or deprotonated molecular ions from the sample via a proton transfer (positive ions) or proton abstraction (negative ions) mechanism. The sample is vaporized in a heated nebulizer before emerging into a plasma consisting of solvent ions formed within the atmospheric source by a corona discharge. Proton transfer or abstraction then takes place between the solvent ions and the sample. Eluent flows up to 2 ml/min can be accommodated without splitting the flow.

APCI Instrument: Quattro Ultima sample size: 1-300 pmole (ideally). If you don’t have 1 pmole, please check with lab staff and see if they can work out an accommodation.